TY - JOUR N2 - Constantly increasing prevalence of allergic diseases determines the attempts to elaborate the therapeutic strategies activating immune tolerance to particular allergen. Our current research focuses on the antigen-specifi c action of CD8+ suppressor T (Ts) lymphocytes induced in mice by intravenous administration of a high dose of haptenated syngeneic erythrocytes. While the regulatory activity of Ts cells mediated by exosome-delivered miRNA-150 is well defi ned, the mechanism of their induction remained unclear. Th erefore, the current studies investigated the immune eff ects induced in mice by intravenous administration of contact allergens coupled to syngeneic erythrocytes. In mouse models of hapten-induced contact hypersensitivity (CHS) and delayed-type hypersensitivity to ovalbumin, we have shown that intravenous administration of hapten-coupled erythrocytes failed to induce CHS effector cells. Moreover, hapten-induced CHS reaction occurred to be suppressed in mice intravenously administered with syngeneic erythrocytes coupled with protein allergen. Finally, we have demonstrated that intravenously administered allergen induces immune tolerance only when bound to syngeneic erythrocytes, proving that intravenously delivered allergens are deprived of their immunizing properties when coupled with membrane of self cells. Altogether, our current studies suggest that alteration of self cell membrane by allergen binding is enough to induce Ts cell-mediated immune tolerance to nonpathogenic agents, which express a great translational potential in such conditions as allergies and hypersensitivity-related autoimmune disorders. L1 - http://czasopisma.pan.pl/Content/111702/PDF/FMC%201-19%205-Nazimek.pdf L2 - http://czasopisma.pan.pl/Content/111702 PY - 2019 IS - No 1 EP - 73 DO - 10.24425/fmc.2019.128026 KW - allergen KW - allergy KW - contact hypersensitivity KW - delayed-type hypersensitivity KW - immune suppression KW - immune tolerance KW - sensitization KW - suppressor T cells KW - tolerogen A1 - Nazimek, Katarzyna A1 - Wąsik, Magdalena A1 - Askenase, Philip W. A1 - Bryniarski, Krzysztof PB - Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum VL - vol. 59 DA - 2019.06.04 T1 - Intravenously administered contact allergens coupled to syngeneic erythrocytes induce in mice tolerance rather than effector immune response SP - 61 UR - http://czasopisma.pan.pl/dlibra/publication/edition/111702 T2 - Folia Medica Cracoviensia ER -