Reports of weed resistance to herbicides have increased in recent years and differentiation in resistance mechanisms is considered to be a concern for the future of weed science. The aim of this work was to characterize the mechanisms of resistance to herbicides associated with Conyza sp. complex and analyze their implications. Aspects of the action of herbicides commonly used in their control will be addressed, in addition to a description of the mechanisms involved in multiple resistance in Conyza species.