This article explores the phenomenon of natural convection in the rotatory flow of Cu-water nanofluid under the influence of non-uniform heat source. In order to design more effective and efficient cooling systems, this work attempts to increase our understanding of how nanofluids behave in the presence of non-uniform heat sources, convection, and rotatory force. The higher order partial differential equations governing the flow are remodelled into ordinary differential equations using similarity transformations. The remodelled equations were solved using shooting methodology and the Lobatto-III A algorithm. The impacts of various parameters such as the Richardson number (1 < Ri < 4), the Schmidt number (0.5 < Sc < 2), nanoparticle’s volume fraction (0.02 < ϕ < 0.08), etc. on velocity, concentration and temperature was ana-lysed. One of the main findings of this analysis was study of the impact of the space dependent heat source (0.2 ≤ A ≤ 1) and the temperature dependent internal heat source (0 ≤ B ≤ 0.5) on the heat regulation. Furthermore, increasing the quantity of the nano-additives and improving the fluid’s thermophysical properties intensified the acceleration of the fluid elements in the flow region. The presence of spatial and temperature-sensitive parameters facilitated quantification of the effects of a standard and variable heat source in combination of Coriolis force in the case of a Cu-water flow. The findings of the investigation will be helpful in the process of medical, architectural planning systems, oil recovery systems and so on.