The strength of backfill is greatly influenced by its inclination angle and interlayer concentration. In order to study the influence of inclination angle and interlayer mass concentration on the strength of backfill, a group of layered cemented backfill with cement-sand ratio of 1:4, interlayer mass concentration of 66%, 67% and 68% and inclination angles of 0°, 10°, 20° and 30° were prepared by using tailings as aggregate. The uniaxial compression test was carried out to analyse the effect of interlayer mass concentration and inclination angle on layered cemented backfill. The crack propagation and energy change law of the specimen during compression were analysed by J-integral and energy conservation law. The relationship between the crack initiation and propagation and strain energy of two representative three-layer backfill specimens was analysed by numerical modelling. The results show that the increase in the layer number and the inclination angle of the backfill can weaken the strength of the backfill. In a certain range of inclination angles, the weakening coefficient of the backfill caused by the inclination angle is very consistent with the cosine value of the corresponding angle. Due to the release of crack energy and the existence of interface J integral, the uniaxial compressive strength of different mass concentration backfill is different at various positions. When the displacement reaches a certain value, the crack and strain energy no longer increase.