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Abstrakt

The effect of Ageratina adenophora on pathological characteristics of the liver and lungs as well as serum biochemical parameters in horses were investigated. Ten horses without ingestion history of Ageratina adenophora were classified into the control group, and 10 poisoned but survived horses with 3 months ingestion history were set as the case group. Results showed that serum AST, ALT, ALP, magnesium and phosphorus were elevated significantly, while creatinine was decreased remarkably. Hematoxylin and eosin staining of liver tissues showed diffuse swelling or destruction of hepatocytes, narrowing or atrophy of the hepatic sinusoids, and little lymphocytic infiltration; lung tissues presented destroyed alveoli and inflammatory cell infiltration.
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Bibliografia


Feldman AT, Wolfe D (2014) Tissue processing and hematoxylin and eosin staining. Methods Mol Biol 1180: 31-43.

Jie F, Hu YC, Chen WH, Weng JH, Hu LW, Zhen S, He YJ, Quan M, Wang Y, Ren ZH (2018) Dosage-dependent effects of Eupatorium adenophorum on Saanen goat blood levels and the histopathology of several organs. Pratacul Sci 2: 11.

O’Sullivan BM (1979) Crofton weed (Eupatorium adenophorum) toxicity in horses. Aust Vet J 55: 19-21.

O’Sullivan BM (1985) Investigations into Crofton weed (Eupatorium adenophorum) toxicity in horses. Aust Vet J 62: 30-32.

Pessoa CR, Pessoa AF, Maia LA, Medeiros RM, Colegate SM, Barros SS, Soares MP, Borges AS, Riet-Correa F (2013) Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys. Toxicon 71: 113-120.

Rhiouani H, El-Hilaly J, Israili ZH, Lyoussi B (2008) Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J Ethnopharmacol 118: 378-386.

Sun W, Zeng C, Yue D, Liu S, Ren Z, Zuo Z, Deng J, Peng G, Hu Y (2019) Ageratina adenophora causes spleen toxicity by inducing oxida-tive stress and pyroptosis in mice. R Soc Open Sci 6: 190127.
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Autorzy i Afiliacje

X.L. Gu
1
F.Y. Dai
1
X. Xiao
1
G.Z. Li
2
L.M. Zhang
1
W.J. Qu
1

  1. College of Veterinary Medicine, Yunnan Agricultural University, Jin Hei Road No.65, Panlong District, 650051, Kunming, P.R. China
  2. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, P.R. China

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