In the paper the experimental analysis of dryout in small diameter channels is presented. The investigations were carried out in vertical pipes of internal diameter equal to 1.15 mm and 2.3 mm. Low-boiling point fluids such as SES36 and R123 were examined. The modern experimental techniques were applied to record liquid film dryout on the wall, among the others the infrared camera. On the basis of experimental data an empirical correlation for predictions of critical heat flux was proposed. It shows a good agreement with experimental data within the error band of 30%. Additionally, a unique approach to liquid film dryout modeling in annular flow was presented. It led to the development of the three-equation model based on consideration of liquid mass balance in the film, a two-phase mixture in the core and gas. The results of experimental validation of the model exhibit improvement in comparison to other models from literature.