The effect of multiple Rushton impellers configurations on hydrodynamics and mixing performance in a stirred tank has been investigated. Three configurations defined by one, two and three Rushton impellers are compared. Results issued from our computational fluid dynamics (CFD) code are presented here concerning fields of velocity components and viscous dissipation rate. These results confirm that the multi-impellers systems are necessary to decrease the weaken zones in each stirred tanks. The experimental results developed in this work are compared with our numerical results. The good agreement validates the numerical method.