In this paper, an advanced study covering the comparison between two classes of generalized inverses is conducted. Two sets of instances, strictly derived from the recently introduced nonunique S- and σ-inverse, are analyzed, especially in terms of degrees of freedom-oriented interchangeable application in different engineering tasks. Henceforth, the respective collections of right and left inverses can be combined in order to achieve a complex tool for robustification of a plethora of real processes. The great potential of two S- and σ-inverse, in particular in robust control and signal recovery as well as complex optimal tasks, is confirmed in the manuscript and supported by the recently carried out research investigations.