Transplantation is a final option for patients with one or several organ failures. The amount of donors is much less than waiting recipients. This article includes selected issues of tansplantation including donors, recipients and medical staff.

3D bioprinting not only represents the future of regenerative medicine, it can also facilitate more precise and more ethical scientific research.

Introduction: Screening sinonasal evaluation is routinely performed before allogeneic hematopoietic cell transplantation (allo-HCT), however, data supporting such evaluation is inconsistent.
Objectives: Assessment of the utility of screening sinonasal evaluation with computed tomography (CT).
Methods: A retrospective analysis of acute leukemia patients who underwent allo-HCT, for whom screening sinonasal CT scans were reevaluated, and for whom Lund-Mackay score (LMS) was calculated.
Results: Forty-eight patients, the median age at allo-HCT 38 years (18–58), 52% males, were included. 79% had acute myeloid leukemia (AML), 21% acute lymphoblastic leukemia (ALL). Conditioning inten-sity was myeloablative in 96% of patients, 21% of patients received total body irradiation. 19% of patients had a history of sinusitis before allo-HCT. Screening sinus CT was performed a median of 22 days before allo-HCT. The median LMS was 1 point (0– 10). The severity of sinus abnormalities was: no abnormalities (31%), mild (67%), moderate (2%), severe (0%). Mucosal thickening was the most frequent abnormality (69%). Eleven patients experienced sinusitis after a median of 93 days (11–607) after allo-HCT. 1-year cumulative incidence of sinusitis was 22%. No threshold of LMS and no type of sinus abnormalities were correlated with sinusitis development after allo-HCT. Mild sinus disease at screening did not negatively impact survival in comparison to no sinus disease.
Conclusions: Despite the fact, that majority of analyzed patients had either no or mild sinus disease at screening a significant proportion of patients developed sinusitis after allo-HCT. Evaluation of LMS before allo-HCT did not help predict the development of sinusitis after the procedure.

This article presents an analysis of Jean-Luc Nancy’s essay L’Intrus (2002), a personal reflection on illness and the experience of heart transplantation. The analysis combines two approaches (though the first of them is given more prominence). Firstly, L’Intrus is treated as philosophical-literary pathography, where the reader’s attention is engrossed by the lived experience of illness and its linguistic representation – a sophisticated, elliptical, metaphorical style which exposes the altering intrusiveness of both the med-ical condition and the treatment (implanting an ‘alien’ organ). Secondly, L’Intrus is read in the context of Jean-Luc Nancy’s philosophical reflection proper. The essay’s linguistic manipulation of singular and plural are interpreted as an echo of his philosophical position put forth in Être singulier pluriel. The totally individual experience of illness and suffering exposes the underlying ontological validity of ‘being-with’ others. The in-sight that there is no being (Dasein) without ‘being-with’ (Mitsein) leads in effect to a revision of a number of key philosophical concepts like the Self / the Other, the subject, identity, nature and technology (ecotechnology).