Aortic stenosis is the most common acquired valvular heart disease. Aortic stenosis has growing prevalence in people older than 75 years and natural course of disease is characterized by high mortality rate. According to epidemiological data all patients with aortic stenosis will die after 2–5 years from the first signs of disease if not undergo aortic valve replacement. However, even 40% of patients do not have surgery because of comorbidities related to advanced age. This was the main reason why in 80- and 90-ties of XX century there were intensive attempt to developed an alternative, less invasive treatment methodology for people with aortic stenosis and comorbidities and at high surgical risk. Transcatheter aortic valve implantation (TAVI) was introduced by Dr Alain Cribier in February 2nd, 2002 in Rouen, France. Since that day different aortic transcatheter bioprostheses were used in many randomized clinical trials comparing their safety and effectiveness versus surgical aortic valve replacement. Gradually, it became clear that in all older patients in all risk groups TAVI was equally or even more safe and effective than surgery. Complications after TAVI are relatively rare, but some of them are life-threatening. Heart Team plays a key role in patients selection to TAVI.
A common problem encountered in hydraulic valves is a progressing deterioration of tightness of their water flow cutting-off seats. The seats are provided usually with a copper-alloy insert joined mechanically with cast-iron valve housing. The problem of unreliability of such joints can be solved by providing surface of the seat with a coating, deposited with the use of HVOF method and resistant to abrasive and cavitation wear. The tests were carried out for a sealing-draining seat insert made of CuZn39Pb2Al brass used to date and a specimen taken from the cast-iron valve housing which was the substrate for a plasma-sprayed coating of powder containing 86.1% Cr, 7.2% Ni, and 6.7% C. The coating, 345 ± 15 μm thick, was characterized with good quality of bonding with cast-iron substrate and high compactness of the material. The cavitation wear test on materials used in the study were carried out with the use of Vibra-Cell ultrasonic liquid processor (Sonics) equipped with a piezoelectric probe operating at the frequency of 20 kHz. Based on profilograms taken along a line crossing centers of cavitation craters, measurements of the height parameter Rt, and microscopic observations of surfaces it has been found that the coating plasma-sprayed onto substrate of nodular cast iron demonstrated higher resistance to cavitation compared to copper-alloy inserts used so far in cast-iron hydraulic valves. Cavitation craters on the material used typically for valve seats to date were more distinctly outlined and deeper compared to craters observed on the coating. Larger were also sizes of local tear-outs which resulted in larger difference between the peaks line and the valleys line.
The pump performance and occurrence of cavitation directly depends on different operating conditions. To cover a wide range of operation conditions for detecting cavitation in this work, investigations on the effect of various suction valve openings on cavitation in the pump were carried out. In order to analyse various levels of cavitation in different operation conditions, the effect of the decrease in the inlet suction pressure of the centrifugal pump by controlling the inlet suction valve opening was investigated using this experimental setup. Hence, the acoustic and pressure signals under different inlet valve openings and different flow rates, namely, 103, 200, 302 l/min were collected for this purpose. A detailed analysis of the results obtained from the acoustic signal was carried out to predict cavitation in the pump under different operating conditions. Also, the acoustic signal was investigated in time domain through the use of the same statistical features. The FFT technique was used to analyse the acoustic signal in the frequency domain. In addition, in this work an attempt was made to find a relationship between the cavitation and noise characteristics using the acoustic technique for identifying cavitation within a pump.
In order to identify the influence of different Mn, Cd, V and Zr content on the properties of Al-Cu casting alloys in hydraulic valves, orthogonal test methods were used to prepare alloy test bars with different elements and contents. Tensile tests were performed on the test bars so obtained. The microstructure of alloys with different compositions is studied. The results show that adding approximately 0.4% of Mn can not only form a strengthening phase but also reduce the excessive segregation of the matrix along the grain boundary. A Cd content of 0.2% can promote the formation of micro Cd spheres in the softer aluminum matrix. Hard spots increase the wear resistance of the material; however, an excess of Cd will cause element segregation and deteriorate the mechanical properties of the valve body. Zr and V refine the grains in the alloy; however, an excess of these elements will lead to a large area of segregation. If proper heat treatment is lacking, the mechanical properties of the valve body deteriorate.
Myxomatous mitral valve disease (MMVD) is a cardiac condition commonly found in older dogs. The disease process can lead to heart failure (HF). In HF, an increase of reactive oxygen species (ROS) and abnormal mitochondrial activity, as well as apoptosis, have been reported. Humanin (HN) is a polypeptide that has a cardioprotective effect against apoptosis and oxidative stress. The purposes of this study were (1) to investigate the potential role of plasma HN as a cardiac biomarker to predict disease progression of MMVD, and (2) to compare plasma HN concentrations with plasma NT-pro BNP concentrations. Thirty-one dogs were included in the study. The dogs were separated into four groups: Group 1 was healthy dogs (n = 8), Group 2 was MMVD class B (n = 8), Group 3 was MMVD class C (n = 8), and Group 4 was MMVD class D (n = 7). All dogs were given a physical examination, thoracic radiography, echocardiography, and samples of their blood were collected for hematology and blood chemistry analysis. Levels of plasma HN and plasma NT-proBNP were also investigated. The results showed that plasma HN levels were lower in the dogs with MMVD and that lower plasma HN levels were associated with greater severity of MMVD-induced HF. It was possible to observe changes in plasma HN levels at a less severe disease stage than plasma NT-proBNP in dogs with MMVD. These findings sug- gest that a decreased plasma HN level can be used as a biomarker to identify dogs with MMVD -induced HF.
This paper investigated the problems and impacts of transient flow in pipeline systems due to pump power failure. The impact of different protection devices was presented to assure surge protection for the pipeline system. A model via Bent-ley HAMMER V8.0 Edition was employed to analyse and simulate hydraulic transients in the pipeline system, and protec-tion alternatives were studied.
Surge protection included using only an air vessel, using an air vessel and two surge tanks, and employing five air ves-sels and vacuum breaker. The obtained results for pressures, heads, and cavitation along the pipeline system were graph-ically presented for various operating conditions. Using five air vessels with vacuum breaker valve as surge protection proved to be more effective and economical against pump power failure.
Changing the flow density did not have a significant impact on the pressures.
For protection with an air vessel; it was concluded that the value 40% of the original diameter for inlet pipe diameter of air vessel, and the value of 2/3 of original pipe diameter were critical values for the transient pressures. Cast iron pipes proved to be the best pipe material for all studied volumes of the air vessel.
For protection with an air vessel and two surge tanks; as the inlet pipe diameters increased the maximum pressures in-creased and the minimum pressures decreased.
Regression analyses were performed obtaining equations to predict the pressures according to the inlet pipe diameter, the area of surge tank, and the pipe diameter.
Proper heart’s nomenclature is very important in daily clinical practice and research studies, and when it is consistent, it can facilitate better communication between different medical specialists. The general rule of the anatomy is to describe organs and their structures in attitudinally correct position. However, the use of the old-fashioned Valentine position (where the heart is described as if it were standing on its apex) is still in use to describe important cardiac structures. Upon closer analysis, all main chambers of the heart and their associated subcomponents have mislabeled structures that should be renamed. In this article we aimed to emphasize the limitations of Valentinian nomenclature, present proper anatomical names of the most important heart’s structures and advocate to change certain mislabeled anatomical structures. Attitudinally correct designations presented in this study will benefit all medical specialties, and they will reinforce the importance of consistent orientational naming. Correct naming of heart’s structures will also help improve communication between different medical specialists.