The topic of incompressible fluid flow in rough channels is of practical interest in many diverse applications. It also forms the basis of our understanding of fluid-wall interactions, turbulent eddy generation, and their effect on the frictional pressure losses. Although this topic is also of fundamental interest, the work in this area is entirely guided by the experimental work of earlier investigators [1–6]. The works by Nikuradse [4] and Colebrook [5] constitute a major milestone from which useful empirical models are derived. As we approach the microscale, Nikuradse’s experimental work again is brought to focus, perhaps this time to gain an insight into the mechanisms affecting fluid-wall interaction in rough channels. In this paper, Nikuradse’s work is revisited in light of the recent experimental work on roughness effects in microscale flow geometries.