The main objective of this work is to present an innovative method of numerical modeling of anchored piles system acting as a road protection against landslide, called the “2D/3D method”. Firstly, short description of the problem and “state of the art” review are included. An effective methodology of the design supported by the numerical analysis, solving the problem of interaction of a periodic system of piles and the unstable soil mass is presented, for which some detailed information about proposed numerical approach is given. The key idea of 2D/3D method is to join the pile with the 2D plane strain continuum by fictitious connectors of Winkler type with P-Y properties identified during the analysis of a subsidiary 3D problem. Practical example of usage of proposed approach to a real case of a road endangered by a landslide then protected by the piles system is presented. On the base of this example, a discussion about important design issues like internal forces in piles (mainly bending moments) and anchors (tensile forces) or overall stability of the soil-structure system is done.