Because the heat release of plutonium material, the composite structure is heated and the stress and strain of the composite structure will increase, which will affect the thermodynamic properties of the structure. The thermodynamic analysis of complex structures, which are composed of concentric structures of plutonium, beryllium, tungsten, explosives, and steel, was carried out. The results showed that when the structure is spherical, the temperature is higher than that of the ellipsoid structure. Stress of the elliptical structure is greater than the spherical structure. This study showed that the more flat the shell is, the greater the stress concentration point occurs at the long axis, and the maximum stress occurs at the beryllium layer. These conclusions provide theoretical support for the plutonium composite component testing.