@ARTICLE{Kozioł_Kamil_Serum_2023,
 author={Kozioł, Kamil and Owczarek, Danuta and Cibor, Dorota and Zwolińska-Wcisło, Małgorzata},
 volume={Vol. 63},
 number={No 3},
 journal={Folia Medica Cracoviensia},
 pages={15-29},
 howpublished={online},
 year={2023},
 publisher={Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum},
 abstract={Objective: Evaluation of serum lactadherin level, its correlation with disease activity and certain biochemical parameters in IBD patients. Methods: The study involved adult IBD patients, comprising 50 with ulcerative colitis (UC), 68 with Crohn’s disease (CD), and 29 healthy controls. Results: The MFGE8 median concentration was significantly higher in UC versus controls (1914.54 vs. 1392.21; p = 0.017), but not in CD. The median MFGE8 levels in UC and CD patient groups didn’t significantly differ. There was a significant inverse correlation between MFGE8 and CRP (r = –0.283; p = 0.044) and fibrinogen (r = –0.362, p = 0.017) in UC. In active UC, MFGE8 median concentration was higher versus controls (1974.36 vs. 1392.21; p = 0.04) and negatively correlated with CRP (r = –0.482; p = 0.005), WBC (r = –0.391; p = 0.027), and fibrinogen (r = –0.473; p = 0.015). Inactive UC showed negative correlation only with fibrinogen (r = –0.567; p = 0.018). No correlations were found with disease activity measured using appropriate scales, age, BMI, or gender. Conclusions: Active UC patients show higher MFGE8 levels. These increase inversely with inflamma-tory markers (CRP, WBC, fibrinogen) in active UC, but not in CD.},
 type={Article},
 title={Serum level of lactadhedrin (MFGE8) in inflamatory bowel disease},
 URL={http://czasopisma.pan.pl/Content/130139/2023-03-FMC-02-Artykuly-02.pdf},
 doi={10.24425/fmc.2023.147212},
 keywords={MFGE8, lactadherin, inflammatory bowel disease, IBD},
}