Assessment of diclofenac LC50 reference values in juvenile and embryonic stages of the zebrafish (Danio rerio)

Journal title

Polish Journal of Veterinary Sciences




No 4


Divisions of PAS

Nauki Biologiczne i Rolnicze


Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn




DOI: 10.2478/v10181-011-0081-0 ; ISSN 1505-1773


Polish Journal of Veterinary Sciences; 2011; No 4


Bendz D. (2005), Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Hoje River in Sweden, J Hazard Mater, 122, 195, ; Buser H. (1998), Occurrence and fate of the pharmaceutical drug diclofenac in surface waters: rapid photodegradation in a lake, Environ Sci Technol, 32, 3449, ; Driever W. (1994), Zebrafish: genetic tools for studying vertebrate development, Trends Genet, 10, 152, ; Ferrari B. (2003), Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac, Ecotoxicol Environ Saf, 55, 359, ; Glassmeyer S. (2005), Effects of chlorination on the persistence of pharmaceuticals in the environment, Bull Environ Contam Toxicol, 74, 24, ; Hallare A. (2004), Developmental toxicity and stress protein responses in zebrafish embryos after exposure to diclofenac and its solvent, DMSO, Chemosphere, 56, 659, ; Halling-Sørensen B. (1998), Occurrence, fate, and effects of pharmaceutical substances in the environment-a review, Chemosphere, 36, 357, ; Chan L. (2001), A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model, Hum Reprod, 16, 2390. ; Jux U. (2002), Detection of pharmaceutical contaminations of river, pond, and tap water from Cologne (Germany) and surroundings, Int J Hyg Environ Health, 205, 393, ; Kotyza J. (2009), Leciva - "Novy" environmentalni polutant, Chem Listy, 103, 540. ; Kovriznych J. (2001), Acute toxicity of selected chemicals in adult zebrafish (<i>Danio rerio</i>) and its early life stages - the comparative study, Biologia, 56, 297. ; Kristensen P. (1994), Sublethal and chronic effects of pollutants on freshwater fish, United nation organization: Fishing news books, 339. ; Luckenbach T. (2001), Fish early life stage tests as a tool to assess embryotoxic potentials in small streams, J Aquat Ecosyst Stress Recov, 8, 355, ; Mehinto A. (2010), Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (<i>Oncorhynchus mykiss</i>), Environ Sci Technol, 44, 2176, ; Nagel R. (2002), DarT: The embryo test with the zebrafish <i>Danio rerio</i> - a general model in ecotoxicology and toxicology, ALTEX, 19, 38. ; Nassef M. (2009), Pharmaceuticals and personal care products toxicity to Japanese medaka fish (<i>Oryzias latipes</i>), J Fac Agric Kyushu Univ, 54, 407. ; Ottmar K. (2010), Development and application of a model to estimate wastewater treatment plant prescription pharmaceutical influent loadings and concentrations, Bull Environ Contam Toxicol, 84, 507, ; Revai T. (1999), Nephrotic syndrome and acute interstitial nephritis associated with the use of diclofenac, Wien Klin Wochenschr, 111, 523. ; Santos L. (2010), Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment, J Hazard Mater, 175, 45, ; Schwaiger J. (2004), Toxic effects of the non-steroidal anti-inflammatory drug diclofenac: Part I: histopathological alterations and bioaccumulation in rainbow trout, Aquat Toxicol, 68, 141, ; Ternes T. (2001), Vorkommen von Pharmaka in Gewassern, Wasser & Boden, 53, 9. ; E. Van den Brandhof (2010), Fish embryo toxicity of carbamazepine, diclofenac and metoprolol, Ecotoxicol Environ Saf, 73, 1862, ; C. Van Leeuwen (1985), Differences in susceptibility of early life stages of rainbow trout (<i>Salmo gairdneri</i>) to environmental pollutants, Aquat Toxicol, 7, 59,