How to search?
advanced search
Medical sciences

Folia Medica Cracoviensia

Folia Medica Cracoviensia

ISSN
ISSN 0015-5616
Publishers
Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum
Editorial Board:


Editor-in-Chief
dr hab. Krzysztof Gil, prof. UJ, Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0002-4732-7698

Vice Editor-in-Chief
Prof. Andrzej Surdacki, 2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0001-7949-3140

Secretary Editor
Prof. Beata Kuśnierz – Cabala, Department of Diagnostics, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0001-8639-5688



Editorial Board Members:

Prof. Benjamin Chain, Department of Infection and Immunity, University College London, London, England

Prof. Paul Enck, Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen Germany

Prof. Tomasz Grodzicki, Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Kraków, Poland

Prof. Kalina Kawecka-Jaszcz, 1st Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland

Prof. Maciej Małecki, Department of Metabolic Diseases, Jagiellonian University Medical College, Kraków, Poland

Prof. Janusz Marcinkiewicz, Department of Immunology, Jagiellonian University Medical College, Kraków, Poland

Prof. Franz H. Messerli, Swiss Cardiovascular Center, University of Bern, Switzerland and Department of Cardiology, Icahn School of Medicine, Mount Sinai Health Center, New York, USA

Prof. Jacek Musiał, 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland

Prof. Wiesław Pawlik, Department of Physiology, Jagiellonian University Medical College, Kraków, Poland

Prof. Jacek J. Pietrzyk, 1st Department of Children's Diseases and the Department of Pediatrics, Jagiellonian University Medical College, Kraków, Poland

Prof. Władysław Sułowicz, Department of Nephrology, Jagiellonian University Medical College, Kraków, Poland

Prof. Jerzy A. Walocha, Department of Anatomy, ,Jagiellonian University Medical College, Kraków, Poland



Adres redakcji
ul. Czysta 18
31-121 Kraków
e-mail: folmedcrac@pan.pl

  • Volumes
  • Instructions for authors

Select number

Content

Folia Medica Cracoviensia | 2024 | vol. 64 | No 3

1 Front page
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 1-2
Download PDF Download RIS Download Bibtex
2 Contents
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 3-4
Download PDF Download RIS Download Bibtex
3 Imiquimod as an effective treatment method of advanced basal cell carcinoma affecting 100-year-old man — case report with literature review
Patrycja Pasieka , Elżbieta Wójtowicz , Wojciech Wysocki , Anna Wojas-Pelc , Andrzej K. Jaworek
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 5–16 | DOI: 10.24425/fmc.2024.152162
Keywords: basal cell carcinoma BCC imiquimod
Download PDF Download RIS Download Bibtex

Abstract

Introduction: Basal cell carcinoma (BCC) is the most common skin cancer with increasing prevalence in the last years. The most important risk factor for development of BCC is exposure to UV radiation. Surgical excision remains the first line treatment, but there are some non-surgical methods of treatment.

The aim of this study is to present a case of 100-year-old patient with advanced BCC in temporal area who refused surgical treatment. The noninvasive treatment with imiquimod was successful.

Case presentation: The 100-year-old male patient was admitted to the dermatological outpatient clinic with an ulceration within the forehead, which had been increasing in size for 3 years. Physical examination revealed shallow irregular ulceration with erythematous pearly-shaped borders in the right temporal area measuring ca. 1.5 cm×2 cm. Dermatoscopic examination of the lesion showed arborising vessels on the semitransparent background, white structureless area and numerous erosions, leading to an initial diagnosis of BCC. Patient refused any surgical interventions within the lesion including skin biopsy. Consequently, treatment with 5% imiquimod was initiated with cream application for 8 weeks, once daily 5 times a week. 8 months after termination of treatment there were no clinical and dermoscopic signs of recurrence of BCC. The patient remains under dermatological follow-up.

Conclusions: Imiquimod seemed to be effective and well-tolerated in treatment of advanced BCC in elderly patients and should be considered in case of contraindications to surgery. Patients with history of skin cancer require long-term observation for local recurrence
Go to article

Authors and Affiliations

Patrycja Pasieka
1
Elżbieta Wójtowicz
2 3
Wojciech Wysocki
4 5 6
Anna Wojas-Pelc
1
Andrzej K. Jaworek
1
  1. Department of Dermatology and Allergology, University Hospital, Krakow, Poland
  2. Skin Cancer and Melanoma Treatment Center, 5th Military Clinical Hospital in Krakow, Krakow, Poland
  3. Polish Dermatoscopy Group
  4. Department of Oncological Surgery, 5th Military Clinical Hospital in Krakow, Krakow, Poland
  5. Chair of Surgery, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland
  6. Maria Skłodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland
4 Coordinate autophagy and translation inhibition enhance cell death in melanoma
Dorota Gil , Marta Zarzycka , Małgorzata Lekka
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 17–35 | DOI: 10.24425/fmc.2024.152163
Keywords: mTOR MNK melanoma eIF4E eIF2α chloroquine
Download PDF Download RIS Download Bibtex

Abstract

Melanoma treatments are necessary when surgically curable treatments are limited. The major challenge of targeted therapy for treating malignant melanoma is acquired drug resistance. Translation and autophagy pathways are interconnected and involved in developing cancer drug resistance.

We hypothesized that coordinate inhibition of autophagy and translation would lead to a better anticancer effect. In the present study, we used chloroquine combined with two translation inhibitors (NVP-BEZ235 and CGP57380) acting at different signaling pathway levels, activating the translation. Our study was conducted for human melanoma cell lines with similar genomic alteration (BRAFV600E and PTEN loss). The combination of the drugs suppresses cell invasiveness and growth by inducing apoptosis. We showed multiple direct and indirect interactions, indicating the overlap and interaction between the translation machinery and autophagy. These data suggest that coordinated inhibition of translation and autophagy promotes apoptosis and may be a new therapeutic model for melanoma treatment.
Go to article

Authors and Affiliations

Dorota Gil
1
Marta Zarzycka
1
Małgorzata Lekka
2
  1. Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
  2. Department of Biophysical Microstructures, Institute of Nuclear Physics Polish Academy of Sciences, Kraków, Poland
5 The pterygoid hamulus: description of its anatomy, topography and clinical implications — a review of literature
Janusz Skrzat , Grzegorz Goncerz , Wojciech Ryniewicz , Magdalena Kozerska , Jerzy Walocha
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 37–45 | DOI: 10.24425/fmc.2024.152164
Keywords: sphenoid bone pterygoid process hamular process pterygoid hamulus
Download PDF Download RIS Download Bibtex

Abstract

The pterygoid hamulus is a bony process that protrudes from the medial pterygoid plate of the sphenoid bone. In spite of its small size and fragile structure, the pterygoid hamulus is an important anatomical structure in many clinical aspects. Orofacial pain may be related to inflammation or irritation of the pterygoid hamulus; if not, other possible explanations should be explored. In addition, the pterygoid hamulus is an important landmark in the oral cavity and is utilized in a number of dental and medical procedures. Thus, the purpose of this work was to review recent studies demonstrating the role and significance of the pterygoid hamulus in clinical practice.
Go to article

Authors and Affiliations

Janusz Skrzat
1
Grzegorz Goncerz
1
Wojciech Ryniewicz
2
Magdalena Kozerska
1
Jerzy Walocha
1
  1. Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland
  2. Department of Prosthodontics and Orthodontics, Institute of Dentistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
6 Ethics in cardiac surgery, the new times. Philosophy in the background
Janusz H. Skalski
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 47–53 | DOI: 10.24425/fmc.2024.152165
Keywords: philosophy of medicine medical ethics deontology cardiac surgical ethics
Download PDF Download RIS Download Bibtex

Abstract

The paper entitled “Ethics in cardiac surgery, the new times. Philosophy in the background” concentrates on the currently most preoccupying issues of medical deontology which are related to practicing the profession of a cardiac surgeon. In the background of his considerations the author refers to the philosophy of medicine. The paper discusses the dilemmas resulting from the lack of understanding of the nature of camaraderie, excessive ambition and responsibility in everyday activity in cardiac surgery. The article ends with sad reflections on the constant problems with which the Polish medicine has to struggle when faced with the degradation of the profession of a physician, excessive bureaucracy, endless haste, legal requirements obligatory in the modern highly commercialized world, underfinancing of the health care sector and shortage of personnel.
Go to article

Authors and Affiliations

Janusz H. Skalski
1
  1. Department of Pediatric Cardiac Surgery, Jagiellonian University Medical College, Kraków, Poland
7 Oral fungal infections in the geriatric population of Municipal Health Centre for Older and Dependent Individuals, and participants of three-month rehabilitation programme — mycological study and clinical correlations
Piotr Michalak , Paulina Polak-Szlósarczyk , Wioletta Dyduch-Dudek , Barbara Kęsek , Elżbieta Zarzecka-Francica , Maria Styrna , Łukasz Czekaj , Joanna Zarzecka
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 55–71 | DOI: 10.24425/fmc.2024.152166
Keywords: seniors oral cavity candidiasis
Download PDF Download RIS Download Bibtex

Abstract

The aim was to analyse the results of the oral mycological examination and the relationship with selected parameters of the questionnaire and clinical examination. The study included 50 residents of the Municipal Health Centre for Older and Dependent Individuals and 30 participants in a three-month rehabilitation programme at the Daily Medical Care House.

The study examined the following: type of prosthetic restorations, hygiene of removable dentures using the Ambjörnsen index, denture stomatitis according to Newton’s classification, pathologies of the oral mucosa according to the classification of Górska and their localisation, mycological examination. Mycological examination was mostly positive (MHCOD 80%, DMCH 81%). The Ambjörnsen index indicated that 72% of residents with a positive mycological result had inadequate denture hygiene. The most frequently isolated fungal species were Candida albicans (89%) and Candida glabrata (39%). In 51% of the cases more than 1 fungal species was isolated. Fungal infection of the oral cavity often took place without accompanying subjective symptoms and increased the risk of red lesions. Abundant and very abundant growth increased a risk of white lesions on the tongue.

Senior patients are at an increased risk of developing oral fungal lesions. As infections often occur without subjective symptoms, it is important to include this group in systematic check-ups. Oral candidiasis is typically identified incidentally during routine examination or in instances of intense proliferation, manifesting as mucosal lesions. This emphasises the role of a detailed examination of the whole mouth. Because of the lack of adherence to proper hygiene is a risk factor for fungal infection, it is crucial to educate both seniors and care staff regarding proper oral hygiene.
Go to article

Authors and Affiliations

Piotr Michalak
1
Paulina Polak-Szlósarczyk
1
Wioletta Dyduch-Dudek
1
Barbara Kęsek
2
Elżbieta Zarzecka-Francica
3
Maria Styrna
4
Łukasz Czekaj
1
Joanna Zarzecka
1
  1. Department of Conservative Dentistry with Endodontics, Institute of Stomatology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
  2. Department of Periodontology, Clinical Oral Pathology and Prophylaxis, Institute of Stomatology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
  3. Department of Prosthodontics and Orthodontics, Institute of Stomatology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
  4. Municipal Health Centre for Older and Dependent Individuals, Kraków, Poland
8 Intestinal microbiome in gestational diabetes — review
Katarzyna Doroszewska , Barbara Zapała , Tomasz Stefura , Tomasz Milewicz
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 73–80 | DOI: 10.24425/fmc.2024.152167
Keywords: gestational diabetes intestinal microbiome gut microbiome
Download PDF Download RIS Download Bibtex

Abstract

Gestational diabetes is one of the most common metabolic complications of pregnancy. Numerous studies have shown the gut microbiota changes significantly during pregnancy and intestinal microbiota also influences the development of diabetes during pregnancy. The aim of this study was to review the studies about gut microbiome in gestational diabetes.
Go to article

Authors and Affiliations

Katarzyna Doroszewska
1
Barbara Zapała
2
Tomasz Stefura
2 3
Tomasz Milewicz
4
  1. Artvimed Medical Center, Kraków, Poland
  2. Jagiellonian University Medical College, Kraków, Poland
  3. The Małopolska Center for Burns and Plastic Surgery, Ludwik Rydygier Memorial Specialized Hospital in Kraków, Kraków, Poland
  4. Department of Gynaecological Endocrinology and Gynaecology, Jagiellonian University Medical College, Kraków, Poland
9 Sequence of procedures used in management of disc displacement without reduction
Małgorzata Pihut , Małgorzata Kulesa-Mrowiecka , Adrian Olszewski , Andrzej Gala
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 81–90 | DOI: 10.24425/fmc.2024.152168
Keywords: TMD disc displacement without reduction physiotherapy biostimulation laser occlusal splint USG of joints
Download PDF Download RIS Download Bibtex

Abstract

Temporomandibular disorder (TMD), occurring in the form of articular disc displacement without reduction is one of the most serious and common forms of dysfunction.

The aim of this article was to present a complete sequence of procedures and intervention that consequently led to the resolution of symptoms in most patients, associated with disc displacement without reduction and the resolution of joint’s pain, as well as favorable results of treatment of disc displacement with reduction. Material and Methods: A group of 128 patients (86 females, 42 males) aged 20 to 42 years old, diagnosed with disc displacement without reduction undertook treatment at the Prosthodontics Clinic of the University Dental Clinic in Krakow, in period January 2020 — June 2024. Diagnosis of the condition was made on the basis of the DC/TMD (Diagnostic Criteria for Temporomandibular Disorders) questionnaire axis I (reduction in mouth opening <35 mm, oblique lowering path of mandibular motion, pain of the joint) and the results of ultrasonography (USG) of the temporomandibular joints. 121 patients reported experiencing intrinsic pain and 7 patients presented for treatment without feeling pain.

Result: Analysis of the results of the carried-out tests (maximal mouth opening, mandibular lowering trajectory deviation and pain intensity VAS + VNRS scale indicate that the displaced articular disc was unblocked and a statistically significant improvement in the clinical condition of the temporomandibular joints was achieved.

Conclusion: The proposed sequence of procedures carried out is an effective treatment for displacement of the articular disc with no reduction.
Go to article

Authors and Affiliations

Małgorzata Pihut
1
Małgorzata Kulesa-Mrowiecka
2
Adrian Olszewski
3
Andrzej Gala
1
  1. Prosthodontic and Orthodontic Department, Dental Institute, Jagiellonian University Medical College, Kraków, Poland
  2. Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland
  3. 2KMM CRO, Katowice, Poland
10 Vitamin D levels in early phase of acute pancreatitis — preliminary study
Mateusz Sporek , Paulina Dumnicka , Barbara Maziarz , Anna Laskowska , Beata Kuśnierz-Cabala
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 91–101 | DOI: 10.24425/fmc.2024.152169
Keywords: vitamin D severe acute pancreatitis early phase of acute pancreatitis
Download PDF Download RIS Download Bibtex

Abstract

Introduction: Recent decades brought important insights into the role of vitamin D, showing, among others, its anti-inflammatory properties. Studies linked vitamin D deficiency with higher incidence and worse outcomes of acute inflammatory conditions. Several studies reported low vitamin D status in acute pancreatitis (AP), however, its association with AP severity is not clear, and there are no such studies in Polish population. The aim of the study was to evaluate the concentrations of 25-OH-D at the early phase (the first three days) of AP, to assess the changes in vitamin D concentrations in that period, and to study the relationship with AP severity.

Materials and Methods: The prospective observational study included adult patients with AP admitted within the first 24 h from the onset of symptoms. Total 25-hydroxyvitamin D was measured at 24, 48 and 72 h from the AP onset, using electrochemiluminescent assay.

Results: Initial 25-OH-D was not associated with AP severity. In patients who developed moderately severe to severe AP and pancreatic necrosis, the decrease in 25-OH-D over two consecutive days was higher comparing to mild AP. The change in 25-OH-D concentrations during the first three days of AP was significantly correlated with inflammatory markers (C-reactive protein, leukocyte count), D-dimer, total calcium, hematocrit, and platelet count.

Conclusions: Our study confirmed the decrease in 25-OH-D in AP; however, it cannot be reliably used as an early prognostic factor of severity in AP as it appears too late from the onset of symptoms and its diagnostic accuracy is low.
Go to article

Authors and Affiliations

Mateusz Sporek
1 2
Paulina Dumnicka
3
Barbara Maziarz
4
Anna Laskowska
5
Beata Kuśnierz-Cabala
3
  1. Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
  2. Surgery Department of the District Hospital in Sucha Beskidzka, Poland
  3. Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
  4. University Hospital in Krakow, Poland
  5. Student’s Scientific Group of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
11 The clinical value of digital occlusal analysis in the treatment of patients with temporomandibular disorders. A review of the literature
Wojciech Maga , Weronika Ciślik , Martyna Schönborn , Małgorzata Pihut
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 103–110 | DOI: 10.24425/fmc.2024.152170
Keywords: temporomandibular disorders TMD bruxism digital occlusal analysis T-Scan Novus
Download PDF Download RIS Download Bibtex

Abstract

Temporomandibular disorders (TMD) are a muscular subset of temporomandibular joint disorders, that can cause orofacial pain. They can be triggered by overactive masticatory muscles due to prolonged disclusion times (DT), occlusal interferences, and occlusal surface friction. Regarding diagnostics, digital occlusal analysis systems are used to determine the parameters of opposing tooth contact and pressure, the ratio of forces on the right and left sides of the oral cavity, to accurately calculate disclusion and occlusion times, and to precisely measure resultant force during maximum and partial intercuspidation. Even though they can be an appropriate tool in modern orthodontic and prosthodontics treatments, these methods are rarely used for patients undergoing multidisciplinary treatment. The aim of this review was to summarize the current knowledge on the clinical application of digital occlusal analysis in the treatment of temporomandibular joint disorders using next-generation systems (T-Scan Novus III, Occlusense) and to identify future research directions for the use of this technology.
Go to article

Authors and Affiliations

Wojciech Maga
1 2
Weronika Ciślik
3
Martyna Schönborn
4
Małgorzata Pihut
1
  1. Department of Prosthodontics and Ortodontics, Jagiellonian University Medical College, Kraków, Poland
  2. Jagiellonian University, Doctoral School of Medical and Health Sciences, Kraków, Poland
  3. University Dental Clinic, Kraków, Poland
  4. 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland
12 The role of magnesium in the prevention and treatment of dental caries — the latest research
Magdalena Stawarz-Janeczek , Anna Curlej-Wądrzyk , Jolanta Pytko-Polończyk
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 111–118 | DOI: 10.24425/fmc.2024.152171
Keywords: magnesium Streptococcus mutans nanoparticles microbiome Mg-rich diet
Download PDF Download RIS Download Bibtex

Abstract

Magnesium is one of the bioelements necessary for proper human functioning. It is classified as a macronutrient. Together with calcium and phosphorus, it is the main building component of teeth. It has antibacterial properties, as consequence of which it can impede the formation of biofilm and thus reduce inflammation caused by bacterial toxins. Along with calcium, phosphorus and vitamins, magnesium helps maintain the health of the human body.

The scientific literature contains an increasing number of studies describing new methods for preventing caries resulting from interference with the oral microbiome. Modification of the microbiome and the use of prebiotics may prove to be groundbreaking. Magnesium may have the potential to function as a prebiotic because it promotes the colonization of commensal streptococci in the oral cavity. By changing the oral microbiome, it could play an important role in dental caries prevention.

Nanotechnology is a new concept of material production that has emerged both in dentistry and other fields. In view of the resistance of certain bacteria to antibiotics and other bactericidal agents, alternative dental materials with increased antibacterial properties are being sought by adding antibacterial nanoparticles (NPs) to their composition. One of the most commonly used metal oxides is magnesium oxide. Its antibacterial action involves disrupting the bacterial cell membrane. It seems that nanoparticles may be promising fillers for dental composites. However, due to the limited character of the clinical trials to date, there is a need for further experiments.
Go to article

Authors and Affiliations

Magdalena Stawarz-Janeczek
1
Anna Curlej-Wądrzyk
1
Jolanta Pytko-Polończyk
1
  1. Department of Integrated Dentistry, Jagiellonian University Medical College, Kraków, Poland
13 Functional impairment of the extremities in patients who got over Complex Regional Pain Syndrome
Andrzej Żyluk
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 119–127 | DOI: 10.24425/fmc.2024.152172
Keywords: Complex regional pain syndrome functional impairment outcome measures questionnaires
Download PDF Download RIS Download Bibtex

Abstract

Complex regional pain syndrome (CRPS) is a descriptive term for a complex of symptoms and signs, including pain, swelling and vasomotor disturbances. The disease causes also functional impairment of the affected extremity and limitation in daily activities. Even after effective treatment, the condition frequently leaves residual symptoms and impairment of the limb.

The objective of this study was assessment of the level of functional impairment in patients who got over CRPS.

Materials and Methods: Fifty-two patients, 45 women (86%) and 7 men (14%) in a mean age of 57 years who were got over CRPS were asked to fill 2 questionnaires for assessment of function of their upper limbs in daily living. The questionnaires included the Raadboud Skills Questionnaire (the RASQ) and the Disability of Arm, Shoulder and Hand (the DASH).

Results of this study show statistically significant differences in functional impairment of the limbs between the groups with different recovery status and duration of CRPS: the patients with longer lasting disease and those, who did not feel recovered showed greater functional impairment of their limbs than remaining patients.

Conclusion: These results suggest that, in spite of a satisfactory outcome of treatment, significant longterm sequelae of the disease impair function of the affected limbs and reduce quality of life in a proportion of patients.
Go to article

Authors and Affiliations

Andrzej Żyluk
1
  1. Department of General and Hand Surgery, Pomeranian Medical University in Szczecin, Szczecin, Poland
14 Computed tomography-derived myocardial extracellular volume fraction — a redundant by-product or a novel promising marker?
Jakub Nowak , Maksym Sikora , Michał Drabik , Maria Kurek , Ewa Wieczorek-Surdacka , Bernadeta Chyrchel , Tadeusz Popiela
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 129–135 | DOI: 10.24425/fmc.2024.152173
Keywords: myocardial fibrosis left ventricular function computed tomography
Download PDF Download RIS Download Bibtex

Abstract

Myocardial extracellular volume (ECV) expansion is associated with myocardial abnormalities such as interstitial fibrosis, inflammation or amyloid deposition. Our aim was to search for correlates of ECV fraction (ECVF) derived from routine cardiac computed tomography (CT) of real-world patients. We retrospectively calculated ECVF from archived chest CT scans performed in 103 patients (51 women and 52 men; mean age: 66 ± 13 years) during a diagnostic work-up based on clinical indications. From recorded echocardiographic images, we calculated indices of left ventricular (LV) structure and function, including systolic (S’) and diastolic (E’ and A’) mitral annular velocities. There were no significant relations between ECVF and clinical or echocardiographic parameters. LV function was comparable according to median ECVF (24.7%) (S’: 10.4 ± 4.1 vs. 9.5 ± 8.0 cm/s; E’: 9.2 ± 3.4 vs. 9.4 ± 3.1 cm/s; E’/A’ ratio: 1.0 ± 0.6 vs. 1.2 ± 0.9; E/E’ ratio: 9.0 ± 4.8 vs. 9.4 ± 5.8 for ECVF above and below the median, respectively). S’ and E’ were positively correlated in 52 subjects with an over-median ECVF (r = 0.46, p = 0.001), in contrast to their 51 counterparts with a below-median ECVF (r = 0.15, p = 0.3). In conclusion, ECV expansion might be associated with a marked interdependence of S’ and E’, corresponding to systolic and early diastolic LV performance, respectively. As E’ is a rough surrogate index of LV active relaxation, these findings could reflect a contribution of LV fibrosis to early LV diastolic dysfunction, known to coincide with discrete LV long-axis systolic dysfun
Go to article

Authors and Affiliations

Jakub Nowak
1
Maksym Sikora
1
Michał Drabik
1
Maria Kurek
1
Ewa Wieczorek-Surdacka
2
Bernadeta Chyrchel
3 4
Tadeusz Popiela
4
  1. Students’ Scientific Group at the Second Department of Cardiology, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
  2. Center for Innovative Medical Education, Jagiellonian University Medical College, Kraków, Poland
  3. Second Department of Cardiology, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
  4. Department of Radiology, Jagiellonian University Medical College, Kraków, Pola
15 Origins of the Bloodstain Pattern Analysis (BPA) with special attention paid to the work of Edward Piotrowski
Maciej Tęsiorowski , Kazimierz Rembiasz , Antoni Czupryna , Wiesław Pawlik , Ryszard W. Gryglewski
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 137–141 | DOI: 10.24425/fmc.2024.152174
Keywords: Forensic medicine BPA Eduard Piotrowski history of medicine
Download PDF Download RIS Download Bibtex

Abstract

Bloodstain Pattern Analysis (BPA) is now an obvious part of forensic medicine, a discipline with its own methodology, scientific aims and practical goals. Roots of it are in experimental work of Polish physician Eduard Piotrowski, with results published in 1895. Significance of it was not immediately recognized. In this paper we aim to show why and how Piotrowski’s model for BPA was finally incorporated into the realm of medical tradition.
Go to article

Authors and Affiliations

Maciej Tęsiorowski
1
Kazimierz Rembiasz
2
Antoni Czupryna
3
Wiesław Pawlik
4
Ryszard W. Gryglewski
5
  1. Department of Orthopaedics and Rehabilitation, University Department of Orthopaedics, Jagiellonian University Medical College, Zakopane, Poland
  2. 2nd Department of General Surgery, Jagiellonian University Medical College, Kraków, Poland
  3. 1st Department of Surgery, Jagiellonian University Medical College, Kraków, Poland
  4. Department of Physiology, Medical Faculty, Jagiellonian University School of Medicine, Kraków, Poland
  5. Department of History of Medicine, Jagiellonian University Medical College, Kraków, Poland
16 The usefulness of computed tomography with the reduction of metal artifacts in the location of an intraorbital foreign body — a case report
Mateusz Dworak , Kamila Stolcman-Mrugała , Zuzanna Gałuszka , Karolina Pasierb , Robert Chrzan , Jacek Składzień
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 143–153 | DOI: 10.24425/fmc.2024.152175
Keywords: foreign body computed tomography eye orbit
Download PDF Download RIS Download Bibtex

Abstract

Intraorbital foreign bodies still remain an unsolved and serious diagnostic problem. Due to the complicated anatomical orbital structure, both the diagnosis and treatment of these injuries are considered to be one of the most challenging. We present a case of a metallic foreign body (a bullet) imbeded in the orbit of a 10-year-old boy. Only after performing computed tomography imaging using the metal artifacts reduction algorithm it was possible to properly localize the foreign body. The issue of intraorbital foreign bodies is interdisciplinary and requires the co-operation between many specialists, including ophthalmologists, otorhinolaryngologists and radiologists.
Go to article

Authors and Affiliations

Mateusz Dworak
1
Kamila Stolcman-Mrugała
1
Zuzanna Gałuszka
1
Karolina Pasierb
1
Robert Chrzan
2
Jacek Składzień
1
  1. Chair and Department of Otolaryngology, Jagiellonian University Medical College, Kraków, Poland
  2. Chair of Radiology, Jagiellonian University Medical College, Kraków, Poland
17 Interleukin-6 single gene polymorphism in patients with inflammatory bowel diseases
Dorota Cibor , Konrad Jabłoński , Danuta Owczarek , Małgorzata Zwolińska-Wcisło
Folia Medica Cracoviensia | 2024 | vol. 64 | No 3 | 155–163 | DOI: 10.24425/fmc.2024.152176
Keywords: ulcerative colitis Crohn’s disease Interleukin 6 genetic polymorphism
Download PDF Download RIS Download Bibtex

Abstract

Objective: Our study aimed to evaluate the association between single nucleotide polymorphism of IL-6-174G/C and the disease course in patients with ulcerative colitis (UC) and Crohn’s disease (CD).

Methods: 105 patients (aged 18–75 years) with diagnosed inflammatory bowel disease (IBD), 50 with CD, and 55 with UC, were involved in the study. The controls consisted of 124 healthy individuals. In all patients, the following parameters were evaluated: disease duration, location, presence of complications, and past surgical procedures. Morphology, biochemical parameters, fibrinogen, interleukin 6 (IL-6) level, and IL-6 single nucleotide (174 G/C) polymorphism were assessed in all subjects. Associations of those markers with disease activity, location, complications, and inflammatory markers were evaluated.

Results: No statistically significant differences in IL-6 single nucleotide (174 G/C) polymorphism were observed between patients with UC, CD, and controls. In IBD patients with the GG genotype, a higher mean IL-6 level was noticed than in patients with other genotypes (4.685 ± 5.9 vs. 2.715 ± 5.1 in GC and 3.186 ± 3.6 in CC). A positive correlation was found between IL-6 and fibrinogen levels and CRP in UC and CD patients with GG and GC genotypes. In IBD patients with CC genotype, no correlation between IL-6 and fibrinogen was found (p = 0.48).

Conclusions: The risk of developing IBD appears not connected with IL-6 polymorphism. However, IL-6 variation might influence the course of the disease in UC patients.
Go to article

Authors and Affiliations

Dorota Cibor
1
Konrad Jabłoński
2
Danuta Owczarek
1
Małgorzata Zwolińska-Wcisło
1
  1. Department of Gastroenterology and Hepatology, Jagiellonian University Medical College, Kraków, Poland
  2. Center for Innovative Medical Education, Jagiellonian University Medical College, Kraków, Poland

Instructions for authors

Manuscripts will be considered for publication in the form of Original Articles or Reviews. Submitted work must comply with ethical policy, which is based on the Committee on Publication Ethics (COPE) guidelines on good publication. (http://publicationethics.org/). Only manuscripts that are previously unpublished, and are not offered simultaneously elsewhere will be considered.
SUBMISSION
Folia Medica Cracoviensia only accepts electronic submission via e-mail at folmedcrac@pan.pl. Manuscripts will be assigned a unique manuscript number that must be quoted in correspondence. Papers and Reviews are refereed by experts in the field; the Editors reserve the right to reject an article without review. Please submit your covering letter or comments to the Editor as well as the names of two potential referees (including name, affiliation, and e-mail address). Currently, Authors have the only option to publish their articles in printed version. The online version will be available soon.
Original Articles
Original Articles describe the results of basic or clinical studies. The length of all Original Articles is limited to 6000 words, excluding acknowledgements and disclosures, references, tables, figures, table legends and figure legends. Please limit the number of figures and tables to a maximum of eight (e.g. four figures and four tables). Color figures can be included as necessary; however authors will be charged a fee (for details please contact editorial office).
Review Articles
Topical reviews of basic or clinical areas are invited by the Editor. Manuscript length is limited to 5000 words and 50 references. All Review articles are subject to review.
Language
The Folia Medica Cracoviensia uses American spelling. Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English.

The complete set of instructions for Authors can be downloaded here as a PDF file: http://www.fmc.cm-uj.krakow.pl/pdf/Author_Guidelines_Folia_2017_Jul_31_KG1.pdf

This page uses 'cookies'. Learn more